The next stage of human evolution is upon us! The world as we know it is about to change, as we begin to prepare for the creation of a new human species. Understanding how this will occur is the basis for understanding the fourth great transformation: our creation of a new human species using artificial intelligence and genetic engineering. Until present, evolution by Darwinian natural selection has determined the emergence of all human species. That will never happen again. We, Homo sapiens, have changed that. Once again, multiple human species will co-exist as a result of our advanced tools which, already, are changing the way we live, the way we eat, the way we treat illness and the way we have children. Understanding these impacts are key to understanding our evolutionary future. The possibilities and opportunities for the humans of 2084 will be more amazing than Orwell's 1984.